Global perspectives on
Mistletoe
Therapy

meet us at WCTCIM
 Rio de Janeiro
 15-18 OCT 2025

Driving Global Innovation in Evidence-Based Mistletoe Therapy

We are pleased to participate in the World Congress on Traditional, Complementary and Integrative Medicine (WCTCIM) in Rio de Janeiro, representing the scientific expertise and clinical practice of mistletoe therapy. Our aim is to expand our international network, foster interdisciplinary exchange, and contribute meaningfully to the global dialogue on integrative oncology.

We invite researchers, patients & stakeholders

Central to our mission is a clear focus on the presentation of mistletoe therapy as an evidence-based complementary treatment option in integrative cancer care — with a particular emphasis on international research and innovation. We are committed to advancing the scientific understanding of mistletoe therapy and promoting its integration into comprehensive cancer treatment models worldwide.

We invite researchers, clinicians, and institutions to connect with us and explore opportunities for collaboration. 

Explore the Evidence

Dive into over 170 key studies on mistletoe therapy – highlighting the clinical evidence, research, and therapeutic relevance of this integrative approach

Browse our clinical studies

Real-World Evidence

Real-world data studies show mistletoe therapy is safe, well accepted, and enhances quality of life — with promising outcomes in advanced cancers 

Browse our RWD studies

Clinical Evidence

Mistletoe therapy is among the most extensively researched treatments in integrative oncology.

To date, 173 clinical studies have investigated anthroposophic mistletoe preparations such as abnobaVISCUM, Helixor, Iscador, and Iscucin. Of these, 97% report positive outcomes — including improved quality of life, better treatment tolerability, and a reduction in side effects, pain, and tumor-related fatigue. Additional findings point to potential tumor remissions, immune-stimulating effects, and even an association with improved overall survival in oncology patients. Preclinical studies support these outcomes, demonstrating cytotoxic and immunomodulatory properties of mistletoe extracts. 

Explore the clinical evidence organized by tumor type, including studies on:

Breast cancer · Colorectal cancer · Lung cancer · Pancreatic cancer · Gastric cancer · Melanoma · Haematological neoplasias, and more.

Explore clinical evidence by tumor type

Mistletoe & Immunotherapy

Initial clinical and real-world data suggest that mistletoe therapy may safely complement immune checkpoint inhibitors (ICIs) in patients with advanced cancers such as lung cancer, melanoma, breast and other cancers. 

Studies indicate that the addition of mistletoe does not increase the rate of adverse effects – in fact, treatment discontinuation due to side effects was lower in the combination group (4.9% vs. 6.4%). Moreover, early data point to a potential survival benefit: patients with advanced non-small cell lung cancer (NSCLC) who received mistletoe alongside PD-1/PD-L1 therapy showed significantly prolonged survival times and, in subgroups, a notable reduction in the risk of death. 

Discover how mistletoe therapy may enhance modern immunotherapies.

Emerging clinical evidence of mistletoe in combinational therapy with immune checkpoints inhibitors.

Explore information on combinatory application

Best Practice in Integrative Oncology

Real cases. Real people. Clinically relevant outcomes in mistletoe case report research

How does mistletoe therapy work in real clinical settings?
Our growing collection of best-practice case reports offers detailed insights into the integrative treatment of various cancer types using mistletoe therapy. These reports illustrate how therapy is applied in practice — including dosing, administration strategies, and observed outcomes — while also reflecting the individual stories behind each case.

We present clinical experiences across a wide range of tumor entities, including:

Skin tumors · Hepatocellular carcinoma · Colorectal cancer · Head and neck tumors · Liposarcoma · Lymphomas · Gastric cancer · Breast cancer · Neuroblastoma · Neuroendocrine tumors · Renal cell carcinoma · Oral cancer · Ovarian cancer · Pancreatic cancer · Pleural mesothelioma · Cervix cancer

View Case Reports here

Patient Empowerment in Care

Comprehensive Answers to Patient's Questions About Mistletoe Therapy

Patients often have many questions when it comes to mistletoe therapy: How does it work? When can it be used? Are there side effects?

Our comprehensive FAQ section offers clear, evidence-informed answers to the most common questions - from general information about mistletoe extracts and their role in integrative oncology to practical guidance on administration, dosage, duration, and potential side effects.

All responses are based on both clinical experience and the latest research, empowering patients and caregivers to have informed conversation with their healthcare providers.

Read frequently asked questions (FAQs)

 

Latest Research

Mistletoe Extract Triggers Immunogenic Cell Death and Boosts Cancer Immunotherapy Potential

A recent in vitro study has shown for the first time that fermented mistletoe extract can induce key features of immunogenic cell death (ICD) in cancer cells. In human breast cancer and murine melanoma cell lines, mistletoe treatment led to the exposure of damage-associated molecular patterns (DAMPs), increased ER stress signaling, and the production of mitochondrial ROS — all markers of ICD, a mechanism essential for making tumors visible again to the immune system.

These findings open up exciting perspectives for the synergistic use of mistletoe therapy alongside immune checkpoint inhibitors, especially in tumors resistant to immunotherapy. Ongoing translational research is exploring how mistletoe extracts may enhance immune recognition, improve therapy response, and contribute to long-term remission in integrative oncology.

Explore Mistletoe-Induced ICD and Other News here

Our speakers & networkers at WCTCIM 2025/Rio de Janeiro

PD Dr. med. Friedemann Schad

PD Dr. med. Friedemann Schad is the head of Oncological Center and Department of Interdisciplinary Oncology, Supportive and Palliative Medicine at the hospital Gemeinschaftskrankenhaus Havelhöhe, Berlin, Germany. He is the author of numerous clinical and translational studies on mistletoe therapy and supportive medicine.

Dr. med. Marion Debus

Dr. Marion Debus, Co‑head of the Medical Section, Goetheanum and former Head of Oncology & Internal Medicine at Klinik Arlesheim, Switzerland, is an international lecturer in anthroposophic oncology. She contributes to global education on integrative cancer care and serves as an expert for the International Misteltoe Website.

Dr. med. Iracema Benevides

Dr. med. Iracema Benevides, a medical doctor and general surgeon specialized in human nutrition, integrative and anthroposophic medicine in Brasil, also holds a master’s in Public Health and Health Policy. She is dedicated to advancing both local and global health systems through her clinical and academic work.

Dr. med. Yván Villegas

Dr. med. Yván Villegas, a distinguished physician, internationally recognized for his expertise in mistletoe therapy, with certifies training in anthroposophic oncology. He lectures worldwide on integrative oncology and actively contributes expertise to international networks and publications on evidence-based cancer care.

Dr. Anja Thronicke (PhD)

Dr. Anja Thronicke, senior researcher at the Research Institute Havelhöhe in Berlin, Germany, focuses on studies in integrative cancer care. She is the author of publications in integrative oncology, including mistletoe therapy as well as art- and movement therapies, with a focus on patient-reported outcomes.

Prof. Dr. Carla Holandino Quaresma

Prof. Dr. Carla Holandino Quaresma is Full Professor at the Federal University of Rio de Janeiro (UFRJ), Brasil and Research Associate at the Society for Cancer Research, Switzerland. A pharmacist with a doctorate in sciences, she focuses on developing anticancer formulations, particularly natural products such as Viscum album L.

Dr. med. Nilo Gardin

Dr. Nilo E. Gardin, a specialist in anthroposophic medicine and hematology in São Paulo, Brasil is a leading researcher in integrative oncology. He is a member of the Brazilian Association of Anthroposophic Medicine (ABMA), serves on the Brazilian Academic Consortium for Integrative Health (CABSIN), and chairs the Brazilian anthroposophic patients’ league (LUAAMA).

Dr. med. Zubin Marolia

Dr. med. Zubin Marolia is an internationally renowned expert in mistletoe therapy, trained at Lukas Klinik, Switzerland, holding a fellowship at Filderklinik, Germany. 34 years' extensive experience treating cancer patients with mistletoe integratively. Worldwide lectures, including at Memorial Sloan Kettering, Johns Hopkins University, U.S., IMM, Germany & the Truth About Cancer series.

 

The Medical Section of the Goetheanum, Dornach, Switzerland, is responsible for the content and design of the mistletoe therapy website (www.mistletoe-therapy.org) and the landing page of the mistletoe website (mistletoe-therapy.org/RIO2025)